NotBlue Formula Rhodiola Rosea, 500mg/capsule, 5mg black pepper - 180 day supply

Rhodiola Rosea + Black Pepper Extract

serving size: 1 capsule, 5mg black pepper

servings per container: 180

daily dose - 500 mg

black pepper extract: 10 mg

other ingredients: Vegetable Cellulose(capsule), Rice Flour

How it can help?

Regulation of Neurotransmitters: Rhodiola rosea may influence the levels of neurotransmitters like serotonin, dopamine, and norepinephrine in the brain. These neurotransmitters play a crucial role in regulating mood, and imbalances in their levels are often associated with depression.  Neuroprotection: Rhodiola rosea contains various bioactive compounds, such as rosavins and salidroside, which possess antioxidant and neuroprotective properties. These compounds may help protect brain cells from oxidative stress and inflammation, which are believed to contribute to depression. Stress Reduction: One of the primary reasons people use Rhodiola rosea is for its potential to reduce the body's stress response. Chronic stress is a significant risk factor for the development of depression, so any herb or substance that helps mitigate stress could indirectly impact depressive symptoms. Energy and Fatigue: Some individuals with depression also experience fatigue and lack of energy. Rhodiola rosea is thought to have potential benefits for increasing energy levels and reducing fatigue, which could indirectly improve the overall well-being of individuals with depression. Hormonal Regulation: Adaptogens like Rhodiola rosea are believed to have an impact on the hypothalamic-pituitary-adrenal (HPA) axis, which plays a role in the body's stress response and hormone regulation. By modulating this axis, Rhodiola rosea might indirectly influence mood and depression.

Benefits:

.: PSYCHIC:

- improves well-being, cognitive functions and supports the nervous system [3]

- helps regulate the nervous system [2]

- increases the level of serotonin in the hypothalamus and midbrain, protecting the nervous system [17,20]

- protects brain tissue in stressful situations [17,20]

- improves concentration [22]

- reduces mental fatigue [22]

- reduces daytime sleepiness [22]

.: STRESS:

- supports the body in coping with emotional stress[2]

- takes care of the nervous system, which supports the body in response to stress [5]

- helps to respond appropriately to stressful factors (physical, chemical and biological) by increasing the body's response to a given type of stressor [16, 17, 18]

- improves the body's ability to adapt to changing environmental conditions [16,17,18]

.: HEART:

- supports the work of the heart by oxygenating and nourishing the cells[1,2,3,4]

- protects the circulatory system against damage [17,20]

- protects heart tissue in stressful situations [17,20]

- protects the heart against stress factors that can damage this organ (e.g. free radicals). [17,21]

- protects the heart against arrhythmia [17,21]

- has an effect on increasing the energy reserves of the heart muscle [17,21]

- reduces local ischemia and regulates blood pressure [17,21]

.: BODY:

- supports physical fitness and condition [5,6,7,8,9,10,11,12,13]

- it should have a normalizing effect on organs and systems in the body, regardless of the direction of changes [16, 17, 18]

- has a beneficial effect on enzyme systems [19]

- helps regulate hormonal balance [19]

- improves physical and psychomotor fitness [22]

- has antioxidant properties [23]

.: DIGESTIVE SYSTEM:

- helps maintain the proper functioning of the digestive system[15]

Research:

1. Darbinyan V., Kteyan A., Panossian A., Gabrielian E., Wikmam G., Wagner H., Rhodiola rosea in stress induced fatigue – A double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty., Phytomedicine, 2000, 7 (5), 365-71.
2. Spasov A.A., Wikman G.K., Mandrikov V.B., Mironova I.A., Neumoin V.V., A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen., Phytomedicine,. 2000, 7 (2) 85-9.
3. Shevtsov V.A., Zholus B.I., Shervarly V.I., Vol’skij V.B., Korovin Y.P., Khristich M.P., Roslyakova N.A., Wikman G., A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work., Phytomedicine, 2003, 10 (2-3), 95-105.
4. Perfumi M., Mattioli L., Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice., Phytother Res., 2007, 21 (1), 37-43
5. Rhodiola rosea. Monograph. 2002. Altern Med Rev, 7, 421-423.
6. Abidov M, Crendal F, Grachev S, Seifulla R, Ziegenfuss T, 2003. Effect of extracts from Rhodiola rosea and Rhodiola crenulata (Crassulaceae) roots on ATP content in mitochondria of skeletal muscles. Bull Exp Biol Med, 136, 585-587.
7. Abidov M, Grachev S, Seifulla RD, Ziegenfuss TN, 2004. Extract of Rhodiola rosea radix reduces the level of C-reactive protein and creatinine kinase in the blood. Bull Exp Biol Med, 138, 63-64.
8. Brown RP, Gerbarg P, Ramazanov Z, 2002. Rhodiola rosea: A Phytomedicinal Overview. HerbalGram, 56, 40-52.
9. De Bock K, Eijnde BO, Ramaekers M, Hespel P, 2004. Acute Rhodiola rosea intake can improve endurance exercise performance. International journal of sport nutrition and exercise metabolism, 14, 298-307.
10. Furmanowa M, Skopinska-Rozewska E, Rogala E, Hartwich M, 1998. Rhodiola rosea in vitro culture: phytochemical analysis and antioxidant action. Acta societatis botanicorum Poloniae, 67, 69-73.
11. Kelly GS, 2001. Rhodiola rosea: a possible plant adaptogen. Altern Med Rev, 6, 293-302.
12. Kucinskaite A, Briedis V, Savickas A, 2004. [Experimental analysis of therapeutic properties of Rhodiola rosea L. and its possible application in medicine]. Medicina (Kaunas), 40, 614-619.
13. Oliff H, 2004. Optimum Dosage of Rhodiola rosea Extract for Antifatigue Effects and Improved Mental Performance. HerbalGram, 63.
14. Gregory S. Kelly Rhodiola rosea: A Possible Plant Adaptogen. Alternative Medicine Review 2001;6(3):293-302;8.www.herbalgram.com. American Botanical Council, HerbalGram 2002, 56,: 40-52. Rhodiola rosea: A Phytomedicinal Overview
15. Piłat TL, Iwanow AA. Gastric Neutral / Gastric Alkaline. P32 Biologicznie aktywne dodatki do żywności (teoria, produkcja, zastosowanie). M .: Avvallon. 2002: 602-604 [w języku rosyjskim]
16. Khanum F., Singh Bawa A., Singh B. Rhodiola rosea: A versatile adaptogen. Comprehensive reviews in food science and food safety. Institute of Food Technologists 2005; 4: 55–62.
17. Brown R., Gerbarg P., Ramazanov Z. Rhodiola rosea: A phytomedicinal overview. Herbal. Gram. 2002; 56: 40–52.
18. Kelly G. S. Rhodiola rosea: A possible plant adaptogen. Alter. Med. Rev. 2001; 6: 293–302.
19. Wolski T., Baj T., Ludwiczuk A., Sałata M., Głowniak K. Surowce roślinne o działaniu adaptogennym oraz ocena zawartości adaptogenow w ekstraktach i preparatach otrzymanych z rodzaju Panax. Post. Fitoter. 2009; 2: 77–97
20. Krajewska-Patan A., Dreger M., Gorska- Paukszta M., Łowicka A., Furmanowa M., Mrozikiewicz P. Rhodiola rosea L. (rożeniec gorski) – stan badań biotechnologicznych. Herba Polonica 2005; 51: 51–64.
21. Wiedenfeld H., Dumaa M., Malinowski M., Furmanowa M., Narantuya S. Phytochemical and ana-lytical studies of extracts from Rhodiola rosea and Rhodiola quadrifi da. Pharmazie 2007; 62: 308–311.
22. Spasov A., Wikman G., Mandrikov V. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic eff ect of Rhodiola rosea SHR-5 extract on the fatique of students caused by stress during an examination period with a repeated low dose regimen. Phytomedicine 2000; 7: 85–89.
23. Lamer-Zarawska E., Kowal-Gierczak B. Fitoterapia i leki roślinne. Warszawa. Wydawnictwo Lekarskie PZWL. 2007.